2010 Fiscal Year Final Research Report
A functional analysis of stabilizing factor BAP1 of cancer-restraining gene BRCA1
| Project/Area Number |
20790939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
NISHIKAWA Hiroyuki St.Marianna University School of Medicine, 医学(系)研究科(研究院), 研究技術員 (90387077)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌遺伝子 |
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| Research Abstract |
BAP1 interacts with BARD1.
BAP1 inhibits the E3 ligase activity of BRCA1 by interfering the BRCA1/BARD1 RING heterodimer formation.
BAP1 is capable of deubiquitinating BRCA1 autoubiquitinated.
BAP1 and BRCA1/BARD1 coordinately regulate ubiquitination during the DNA damage response and the cell cycle.
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