2011 Fiscal Year Final Research Report
Study of Carboxypeptidase M expression profiles in patients with lung cancer
| Project/Area Number |
20790982
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJIWARA Naoyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 医系・助教 (80451912)
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| Co-Investigator(Kenkyū-buntansha) |
AKASHI Takumi 東京医科歯科大学, 医学部附属病院, 医系・准教授 (60242202)
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| Project Period (FY) |
2008 – 2011
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| Keywords | カルボキシペプチダーゼM / Carboxypeptidase M / CPM / 肺がん / Lung Cancer / 肺胞上皮細胞 / 発がん動物モデル |
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| Research Abstract |
We investigated the localization of CPM in lung cancer of human and rat. Anti-rat CPM antibody 7F9 was applied to a BHP-induced rat lung cancer model. In immunohistochemistry, CPM was localized in the cell membrane of pulmonary alveolar type II epithelial cells in normal tissue part, and also was in the cell membrane of pulmonary cancer part. In immunohistochemistry for CPM and TTF-1, positive cells were well consistent. Expression level of CPM in western blotting was increased with time. Therefore, CPM was considered one of the cancer-related molecules.
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