2009 Fiscal Year Final Research Report

Analysis of function of bone morphogenetic protein signaling in bone remodeling and osteoclast formation

Research Project

Project/Area Number	20791033
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Osaka University
Principal Investigator	OKAMOTO Mina Osaka University, 医学系研究科, 特任研究員 (50457008)
Project Period (FY)	2008 – 2009
Keywords	骨形成因子 / コンディショナルノックアウトマウス / 破骨細胞 / 骨代謝 / カテプシンK
Research Abstract	Bone morphogenetic protein (BMP) is an important protein in the skeletal metabolism. So far it is known that BMP signaling promote osteoblastic differentiation, but its role in osteoclasts is not clear. So we analyzed the key role of BMP signaling in osteoclast. We found that BMP signaling in bone remodeling plays an important roles in the osteoclast, and we considered it is necessary for bone tissue formation and maintenance.