2010 Fiscal Year Final Research Report
Analysis of cytokine secretion and its application using macrophage specific syntaxin 3 knockout mice
| Project/Area Number |
20791063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | シンタキシン3 / ノックアウトマウス |
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| Research Abstract |
Using macrophage specific syntaxin 3 knockout mice, whether syntaxin 3 was involved in the secretion of TNFα, it was evaluated by staining and ELISA. Unlike the initial estimates,the syntaxin 3 was not found to be involved in the secretion of TNFα. However, syntaxin 3 to move from the Golgi apparatus to the cell periphery, It was thought it is involved in the secretion of other cytokines.
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