The influences of the anesthetics on inhibitory interneurons and dopamine release in reward neural circuit in rats.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791087
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: ISHIWA Dai Yokohama City University, 医学研究科, 客員研究員 (30457858)
• Project Period (FY): 2008 – 2009
• Keywords: 麻酔学

Research Abstract

To clarify the cellular mechanisms of addiction with anesthetics, I performed extracellular field potential recording on rat VTA slices. I found that subclinical concentration of propofol (0.5μM) potentiated the field potential in VTA about 25 % of control value even though much higher concentration of propofol (5-50μM) suppressed it dose dependently. I could not evaluate influences of propofol in dopamine release in the VTA with in vitro setting.