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2010 Fiscal Year Final Research Report

Identification of molecular mechanism of excitement with inhalational anesthetics

Research Project

  • PDF
Project/Area Number 20791096
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJikei University School of Medicine

Principal Investigator

YASUI Yutaka  Jikei University School of Medicine, 医学部, 助教 (80459651)

Project Period (FY) 2008 – 2010
Keywords吸入麻酔薬 / 青斑核 / 興奮
Research Abstract

The purpose of the present study is to identify the molecular mechanism of the excitement with the inhalational anesthetics. According to the membrane potential recordings of locus coeruleus neurons, it was shown that PKC took part in the excitement of locus coeruleus caused by sevoflurane. Moreover, the behavioral analysis device was made, and the behavior of the rat was expressed numerically. Interestingly, the order in generating inward current for three volatile anesthetics (sevoflurane, isoflurane and halothane), especially the fact that the inward current with sevoflurane was larger than that with halothane, is in complete accord with the behavioral studies showing that sevoflurane provokes the agitation at the strongest in the rat among these anesthetics. The excitatory current activated by sevoflurane in LC neurons might be one of the potential cellular mechanisms underlying paradoxical excitatory effect of sevoflurane.

  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.2010

    • Author(s)
      R.Aoyama, Y.Okada, S.Yokota, Y.Yasui, K.Fukuda, Y.Shinozaki, H.Yoshida, M.Nakamura, K.Chiba, Y.Yasui, F.Kato, Y.Toyama.
    • Journal Title

      Pain. (in press).

    • Peer Reviewed
  • [Journal Article] Treatment of particle-associated pulmonary aspiration with bronchoscopic lavage: report of two cases.2009

    • Author(s)
      Yasui, Y, Kida, K, Ohtani, N, Aida, S, Masaki, E.
    • Journal Title

      Eur J Anaesthesiol. 26(6)

      Pages: 527-529

    • Peer Reviewed
  • [Journal Article] Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery.2008

    • Author(s)
      K Kida, N Ohtani, K Shoji, Y Yasui, E Masaki.
    • Journal Title

      European Journal of Anaesthesiology. 25

      Pages: 869-875

    • Peer Reviewed
  • [Journal Article] Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery.2008

    • Author(s)
      Ohtani N, Kida K, Shoji K, Yasui Y, Masaki E.
    • Journal Title

      Anesth Analg. 107(6)

      Pages: 1871-1874

    • Peer Reviewed
  • [Journal Article] セボフルランによるラット青斑核ニューロンの直接的興奮2008

    • Author(s)
      安井豊
    • Journal Title

      Anesthesia Network Vol.12

      Pages: 44-49

  • [Presentation] 根津武彦受傷時の呼吸停止から呼吸器離脱に至った高位頚髄損傷の-症例2011

    • Author(s)
      安井豊、藤原千江子、宮崎愛佳、松田祐典、飯田瑠梨
    • Organizer
      第38回日本集中治療医学会学術集会:DP-79-2
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
  • [Presentation] 2度の全身麻酔下手術後に味覚障害が生じた1症例2010

    • Author(s)
      藤原千江子、藤井輝之、斉藤千恵、小崎佑吾、安井豊、生田目英樹、根津武彦
    • Organizer
      第37回日本集中治療医学会学術集会:DP-42-1
    • Place of Presentation
      横浜
    • Year and Date
      20100304-20100306
  • [Presentation] Efficacy of Intrathecal Esmolol on Heat Evoked Responses in a Postoperative Pain Model2010

    • Author(s)
      N.Ohtani, Y.Tachibana, A.Aoi, Y.Yasui, E.Masaki.
    • Organizer
      2010 American society of anesthesiologists Annual Meeting : A288
    • Place of Presentation
      2010 San Diego, CA
    • Year and Date
      2010-10-18
  • [Presentation] 導入及び覚醒時興奮のメカニズムを求めて-セボフルレンによる青斑核ニューロンの興奮Molecular and cellular mechanisms of anesthetic-induced agitation S03-062010

    • Author(s)
      安井豊
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
  • [Presentation] Perioperative Infusion of Dexmedetomidine at High Dose Reduces Postoperative Analgesic Requirement2008

    • Author(s)
      N.Ohtani, K.Kida, Y.Yasui, K.Shoji, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A552
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-22
  • [Presentation] Intraoperative Infusion of Dexmedetomidine Decreases Postoperative Pain Scores:A Meta-Analysis2008

    • Author(s)
      K.Kida, Y.Yasui, N.Ohtani, N.Kuratani, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A1625
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-21
  • [Presentation] Dexmedetomidine Counteracts the Excitatory Effect of Sevoflurane on LC Neurons of the Rat2008

    • Author(s)
      Y.Yasui, Y.Okamoto, K.Shoji, F.Kato, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A718
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-18

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Published: 2012-02-13   Modified: 2016-04-21  

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