Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Iwate Medical University
• Principal Investigator: OBARA Wataru Iwate Medical University, 医学部, 講師 (90337155)
• Project Period (FY): 2008 – 2010
• Keywords: 進行性腎細胞癌 / 活性型ビタミンD3 / 抗腫瘍効果 / 個別化医療

Research Abstract

The exogenous vitamin D had no effect for normal kidney cell and showed the activation of the vitamin D metabolic pathway with activity of CYP24. Vitamin D3 had the suppression of the renal carcinoma cell proliferation and the mechanism of action was caused by induction of apoptosis and the cell cycle arrest. Activity of CYP24 also increased by combination of molecular target medicine and vitamin D3 and showed augmentation of the cytostatic effect.

Research Products

• [Journal Article] Evidence-based clinical practice guidelines for renal cell carcinoma (Summary-JUA 2007 Edition). (2009)
  • Author(s): Fujioka T, Obara W.
  • Journal Title: Int J Urol 16 Pages: 339-353
• [Journal Article] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinoma. (2008)
  • Author(s): Obara W, Mizutani Y, Oyama C, Akaza H, Ishii N, Kohri K, Namiki M, Okuyama A, Shima H, Yokoyama M, Shuin T, Miki T, Watanabe Y, Fujioka T.
  • Journal Title: Int J Urol 15 Pages: 794-799
• [Journal Article] Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma. (2007)
  • Author(s): Obara W, Konda R, Akasaka S, Nakamura S, Sugawara A, Fujioka T.
  • Journal Title: J Urol. 178 Pages: 1497-503
• [Journal Article] Vitamin D receptor gene polymorphisms are associated with increased risk and progression of renal cell carcinoma in a Japanese population. (2007)
  • Author(s): Obara W, Suzuki Y, Kato K, Tanji S, Konda R, Fujioka T.
  • Journal Title: Int J Urol. 14 Pages: 483-487
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