2009 Fiscal Year Final Research Report
Integrative genomic analysis and screening of microRNA expression status in endometrial cancer.
| Project/Area Number |
20791165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
HIRASAWA Akira Keio University, 医学部, 助教 (90296658)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 子宮体癌 / ゲノム異常 / メチル化 / マイクロRNA |
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| Research Abstract |
MicroRNAs (miRNAs) are small non-coding RNAs and negative regulators for their gene targets. Although the tumor-suppressive functions of several miRNAs have been demonstrated, the dysregulation of miRNAs and their molecular mechanisms in endometrial cancer still remain unclear. To identify tumor-suppressive miRNAs (TS-miRs) silenced by DNA hypermethylation during endometrial carcinogenesis, we performed functional screening for TS-miRs in endometrial cancer cell lines. We further analyzed DNA hypermethylation of CpG-islands around mature miRNAs, resulting in identification of some miRNAs as the candidate TS-miRs silencing by CpG island hypermethylation. Our data suggest that these TS-miRs might play an important role in endometrial carcinogenesis.
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[Journal Article] Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer2008
Author(s)
Sugano K, Nakamura S, Ando J, Takayama S, Kamata H, Sekiguchi I, Ubukata M, Kodama T, Arai M, Kasumi F, Hirai Y, Ikeda T, Jinno H, Kitajima M, Aoki D, Hirasawa A, Takeda Y, Yazaki K, Fukutomi T, Kinoshita T, Tsunematsu R, Yoshida T, Izumi M, Umezawa S, Yagata H, Komatsu H, Arimori N, Matoba N, Gondo N, Yokoyama S, Miki Y.
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Journal Title
Cancer Sci 99
Pages: 1967-1976
Peer Reviewed
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[Journal Article] Nishimura S, Tsuda H, Miyagi Y, Hirasawa A, Suzuki A, Kataoka F, Nomura H, Chiyoda T, Banno K, Fujii T, Susumu N, Aoki D.2008
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[Presentation] Analysis of UGT1A1 *6, *27, *28 and *60polymorphism and serum bilirubin levels for individualized cancer therapy using irinotecan2009
Author(s)
Hirasawa A, Akahane T, Tsuruta T, Kobayashi Y, Nomura H, Banno K, Saito K, Zama T, Tanigawara Y, Susumu N, Aoki D.
Organizer
The 4th Asian Confernce on Pharmacoepidemiology
Place of Presentation
Tainan, Taiwan
Year and Date
20091023-20091025
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[Presentation] Effects of UGT1A1 polymorphism on irinotecan-induced drug reaction and serum bilirubin levels2009
Author(s)
Hirasawa A, Akahane T, Tsuruta T, Kobayashi Y, Nomura H, Banno K, Tsuda H, Saito K, Zama T, Tanigawara Y, Susumu N, Aoki D.
Organizer
The 59th Annual Meeting of The American Society of Human Genetics
Place of Presentation
Hawaii, USA
Year and Date
20091020-20091024
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[Presentation] Pitfalls in fertility-preserving high-dose medroxyprogesterone acetate (MPA) therapy for young patients with endometrial cancer - A retrospective study of 23 patients who subsequently underwent hysterectomy-2009
Author(s)
Susumu N, Hirasawa A, Kobayashi Y, Tsuruta T, Ichikawa Y, Yamagami W, Nomura H, Kataoka F, Suzuki A, Bannno K, Tsuda H, Aoki D.
Organizer
16th International Meeting of the European Society of Gynaecological Oncology
Place of Presentation
Belgrade, Serbia
Year and Date
20091011-20091014
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[Presentation] Pharmacogenomic effects of UDP-glucuronosyltransferase 1A1 on irinotecan-induced drug reaction and serum bilirubin levels2009
Author(s)
Hirasawa A, Akahane T, Tsuruta T, Nomura H, Banno K, Tsuda H, Saito K, Zama T, Tanigawara Y, Susumu N, Aoki D.
Organizer
2009 European Human Genetics Conference
Place of Presentation
Vienna, Austria
Year and Date
20090523-20090526
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[Presentation] Analysis of UGT1A1 polymorphism and serum bilirubin levels for individualized cancer therapy using irinotecan2008
Author(s)
Hirasawa A, Akahane T, Yamagami W, Nomura H, Banno K, Tsuda H, Naganishi H, Okubo K, Saito K, Zama T, Tanigawara Y, Susumu N, Aoki D.
Organizer
67th Annual meeting of the Japanese cancer assosiation
Place of Presentation
Nagoya Japan
Year and Date
20081028-20081030
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[Presentation] Association of Genetic Variants of UDP-glucuronosyltransferase 1A1 Gene with Serum Bilirubin Level in the Japanese2008
Author(s)
Hirasawa A, Tsuruta T, Nomura H, Kataoka F, Tominaga E, Banno K, Suzuki A, Tsuda H, Naganishi H, Saito K, Zama T, Tanigawara Y, Susumu N, Aoki D
Organizer
2008 International Conference on Pharamagogenomics
Place of Presentation
Busan, Korea
Year and Date
20080409-20080412
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