2010 Fiscal Year Final Research Report
Effects to inhibit innate immunity of fungi, especially Alternaria-Experiments using dendritic cell-
Project/Area Number |
20791231
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
WADA Kota Jikei University School of Medicine, 医学部, 助教 (20307482)
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Project Period (FY) |
2008 – 2010
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Keywords | Alternaria / 樹状細胞 / 線維芽細胞 / 自然免疫 |
Research Abstract |
Alternaria alternate extract induced IL-6 and IL-8 production from nasal fibroblasts in dose and time dependent manner. Alternaria alternate which treated at 56, 100℃ did not induce IL-6 and IL-8. It is suggesting that these production occurred by a heat-labile protein(s) or glycoprotein(s). From inhibition assay, Asparte protease-like product, not serine protease, is one of the products of alternaria alternate for these reactions. P38 MAP kinase plays an important role for IL-6 and IL-8 production by alternaria alternate from nasal fibroblasts. We were not able to examine the experiment of dendritic cells. We assume it the problem of the study after the next year.
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