2009 Fiscal Year Final Research Report
Epithelial-Mesenchymal Transition of Retinal Pigment Epithelium in Age-related Macular Degeneration in SOD1 dificient mice.
| Project/Area Number |
20791269
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
HIRASAWA Manabu Keio University, 医学部, 助教 (80365345)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 加齢黄斑変性 / 上皮間葉移行 / 酸化ストレス |
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| Research Abstract |
We focused on epithelial-mesenchymal transition(EMT)-like changes of retinal pigment epithelium cells(RPE) in age-related macular degeneration(AMD) and observed transcriptional factors relate to EMT. We analyzed age-related changes of retina from SOD1 deficient mice, recognized as oxidative stress model mice, and found out about retinal degeneration with aging and disruption of cell-cell contact of RPE, however, transcriptional factors relate to EMT were not detected in RPE. Otherwise we observed nuclear localization of Snail about RPE from surgically exicised choroidal neovascularization membrane secondary to AMD.
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[Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice2008
Author(s)
Hashizume K, Hirasawa M, Imamura Y, Noda S, Shimizu T, Kurihara T, Noda K, Shinoda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K.
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Journal Title
Am J Pathol 172
Pages: 1325-1331
Peer Reviewed
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