2009 Fiscal Year Final Research Report
detecting heterogeneity of neuroblastomas with a whole genetic analysis using SNP array
| Project/Area Number |
20791301
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
RYOTA Souzaki Kyushu University, 大学病院, 医員 (10403990)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 神経芽腫 / SNPアレイ / 生物学的多様性 |
|---|
| Research Abstract |
We thought that a small change of dosage of the MYCN gene due to intratumoral heterogeniety and a chromosomal gain of MYCN gene affected the prognosis in neuroblastoma. Therefore, the microdissection and SNP array were performed to determine the dosage of the MYCN gene and we found tha cases with a small number of MYCN amplified cells and a large number of MYCN gain cells. It was thought that a judgment of more accurate MYCN amplification was necessary using LCM and SNP array analysis in future
|
