2009 Fiscal Year Final Research Report
Inhibition of bone resorption by RNA aptamer for immunoregulatory receptor PD-1 induced on activated T cell.
| Project/Area Number |
20791350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAHASHI Mariko Tokyo Medical and Dental University, 歯学部, 技術職員 (90334440)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 破骨細胞 |
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| Research Abstract |
PD-1 is a negative regulator of immune responses. We made a hypothesis that PD-1 is involved in inflammatory bone resorption and that PD-1 signal has possibilities as a drug target which inhibit inflammatory bone resorption. RNA aptamer for PD-1 might be a candidate and thus we tried to make an aptamer. During the research period, it was technically difficult to make the aptamer and to investigate the effect. To get basic knowledge of more effective and safety medical product, it is important to create new drug-discovery technology like an aptamer in the future.
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