2009 Fiscal Year Final Research Report
Identification of osteoclast niches regulatory factor produced by osteoblasts
| Project/Area Number |
20791365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
MIZOGUCHI Toshihide Matsumoto Dental University, 総合歯科医学研究所, 講師 (90329475)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 骨吸収 / マクロファージ / 破骨細胞 / 破骨細胞前駆細胞 / ニッチ / RANKL / M-CSF / 細胞周期 |
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| Research Abstract |
We have identified "cell cycle-arrested quiescent osteoclast precursors : QuOPs" as the direct precursors of osteoclasts in vivo. In the present study, we examined characteristics of QuOPs in vivo. QuOPs were detected in mouse bone marrow and peripheral blood. QuOPs were circulated from peripheral blood into bone tissue in response to bone resorption-inducing stimuli. RANKL and c-Fos were not necessary for differentiation of circulating-QuOPs. c-Fos was necessary for maturation of QuOPs in the bone surface.
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Research Products
(21 results)
