2009 Fiscal Year Final Research Report
lnvolvement of non-coding gene U50HG and U50 snoRNA in lymphatic system
| Project/Area Number |
20791374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SOENO Yuuichi The Nippon Dental University, 生命歯学部, 講師 (70350139)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 実験腫瘍学 |
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| Research Abstract |
To elucidate the not-yet-known function of U50 snoRNA we generated an mU50-deficient mouse line. In this mouse line, mU50-targeted methylations on the rRNA were reduced as with the reduction of mU50 expression. The mU50-deficient mice were indistinguishable from wild-type littermates at sight, but some of those animals were prone to have defects in lymphatic organs. Regarding to the strong U50 expression in hematopoietic lineages, promoter analyses revealed the involvement of c-MYC and BCL6 in the transcription of the host-gene.
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[Presentation] A mouse model lacking U50 box C/D-type snoRNA expression2009
Author(s)
Soeno, Y., Fujita, K., Kudo, T., Taya, Y., Aoba, T.
Organizer
The 14th Annual Meeting of the RNA Society
Place of Presentation
Madison, WI, USA
Year and Date
20090000
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