2009 Fiscal Year Final Research Report
Biomaterials immunization using a novel peptide that binds to a PMMA denture
| Project/Area Number |
20791415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KEN-ICHIRO Komaki Tohoku University, 病院, 助教 (40361109)
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| Project Period (FY) |
2008 – 2009
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| Keywords | PMMA / ペプチド / インターフェイス |
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| Research Abstract |
We used a peptide library for iolating peptide aptamers against PMMA powder. We observed that 7 of 18 phages displayed on their surfaces peptides having the identical sequence. We confirmed that the predominant phage retained the ability to bind to PMMA powder and also PMMA plate. The binding of biomolecules that bring active biological function to the surface of PMMA is critical clinically. Using fusion proteins of the iolated peptide motif and functional biomolecule, we expect to add the ability to immunize on PMMA surface.
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