2011 Fiscal Year Final Research Report
Study of involvement of sensory neurons in bone defect repair in rats with capsaicin-induced sensory denervation
| Project/Area Number |
20791488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAMURA Megumi 東北大学, 大学院・歯学研究科, 助教 (20431512)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 骨 / 修復 / 感覚神経 / カプサイシン / リモデリング / X線画像解析 / real-time PCR / ラット |
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| Research Abstract |
We investigated bone repair in sensory-denervated rats. Nine-week-old male Wistar rats received subcutaneous injections of capsaicin to denervate sensory neurons. Rats treated with the same amount of vehicle served as controls. A standardized bone defect was created on the parietal bone. We measured the amount of repaired bone with quantitative radiographic analysis and the mRNA expressions of osteocalcin and cathepsin K with real-time PCR. The results suggested that capsaicin-induced sensory denervation affects the bone defect repair and remodeling.
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