2009 Fiscal Year Final Research Report
The global analysis of N-α-acetylome that is aiming development of antitumor therapy by the target factor in oral cancer.
| Project/Area Number |
20791511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tottori University |
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Principal Investigator |
TAKUBO Kazuko Tottori University, 医学部附属病院, 助教 (90379628)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アセチローム / αアセチル化 / 細胞死 / 細胞周期 |
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| Research Abstract |
N-acetyltransferase human (NATH) participates in a posttranslational modification of the proteins and has been reported to play a role in apoptosis. In this study, the involvement of NATH in the cytotoxic action of 5-fluorouracil (5-FU) in human squamous cell carcinoma HEp-2 cells was examined. We found that 5-FU decreased NATH expression in a dose-dependent and time-dependent manner. No change was observed after treatment with other chemotherapeutics. The results of this study suggest that NATH plays an important role in the cytotoxic activity of 5-FU.
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[Journal Article]
Author(s)
Kazuko Takubo, Hiroyuki Tsuchiya, Akihiro Kurimasa, Thomas Arnesen, Kazuo Ryoke, Goshi Shiota
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Journal Title
Peer Reviewed
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