2009 Fiscal Year Final Research Report

Clinical analysis of anti-sideroflexin 3-autoantibody as a novel tumor marker for oral squamous cell carcinoma.

Research Project

Project/Area Number	20791529
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Ehime University
Principal Investigator	MURASE Ryuichi Ehime University, 医学部・附属病院, 医員 (70452696)
Research Collaborator	SUMIDA Tomoki 愛媛大学, 大学院・医学系研究科, 大学院生 (50314951) AMANO Yoshiyuki 三洋化成工業医療産業, 分社長
Project Period (FY)	2008 – 2009
Keywords	口腔扁平上皮癌 / 腫瘍マーカー / 早期診断
Research Abstract	The purpose of this study is to establish a tumor marker that can be applied for the early detection and follow-up oral cancer patients. Employing the proteomic approach using MALDI TOF-MS, 2-DE, patient's sera and culturing cell lines, a mitochondrial membrane protein, sideroflexin 3 (SFXN3), was identified. The serum anti-SFXN3-autoAb levels elevated in patients with oral squamous cell carcinoma significantly: with 72% sensitivity and 81% specificity against control samples. Changes in serum anti-SFXN3-autoAb levels after therapy correlated with the clinical tumor burden.

(4 results)