2009 Fiscal Year Final Research Report
Roles of Odz3 in primary cartilage during mandibular condylar development
| Project/Area Number |
20791565
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKESHITA Nobuo Tohoku University, 大学院・歯学研究科, 助教 (50431515)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Odz3 / 下顎頭 / 軟骨 / ATDC5 |
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| Research Abstract |
Mandibular condyle has been speculated to develop by differentiation of fibroblast-like cells covering the condyle to chondrocytes ; however, the developmental mechanisms have not been revealed. We used laser-captured microdissection and cDNA microarray analysis to obtain the genes highly expressed in fibroblast-like cells ; one of these genes was Odz3. The temporal and spatial expression of Odz3 mRNA was revealed in mandibular condylar cartilage during early developmental stage in mice and ATDC5 cells, a mouse chondrogenic cell line. These findings suggest that Odz3 might act as a regulatory factor in the early developmental stage of mandibular condylar cartilage.
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Research Products
(3 results)
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[Journal Article] Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.2009
Author(s)
Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M
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Journal Title
Dev Biol. 328
Pages: 315-327
Peer Reviewed
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