The effect of cathepsin E on orthodontic tooth movement

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791585
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: FUJIMURA Yuji Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (70448504)
• Project Period (FY): 2008 – 2009
• Keywords: 歯の移動 / 破骨細胞 / カテプシンE

Research Abstract

The aim of this study was to investigate the effect of cathepsin E on TNF-α induced osteoclast differentiation and orthodontic tooth movement. The numbers of TNF-α induced osteoclasts were not significantly different between WT mice and cathepsin E knockout mice. Moreover, the distance of tooth movement was also not significantly different. These results suggest that cathepsin E have no effect on TNF-α induced osteoclast. Therefore it is not prevent orthodontic tooth movement.

Research Products

• [Journal Article] Influence of bisphosphonates on orthodontic tooth movement in mice (2009)
  • Author(s): Yuji Fujimura, Hideki Kitaura, Masako Yoshimatsu, Toshiko Eguchi, Haruka Kohara, Yukiko Morita, Noriaki Yoshida
  • Journal Title: European Journal of Orthodontics 31(6) Pages: 572-577
  • Peer Reviewed
• [Presentation] Effect of Bisphosphonates on Orthodontic Tooth Movement in Mice (2009)
  • Author(s): Yuji Fujimura, Hideki Kitaura, Masako Yoshimatsu, Haruka Kohara, Yukiko Morita, Toshiko Eguchi, Teruko Takano-Yamamoto, Noriaki Yoshida
  • Organizer: The 31th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Colorado Convention Center, Denver, CO, USA
  • Year and Date: 20090911-20090915