2010 Fiscal Year Final Research Report
The relationship between Arteriosclerotic disease and Periodontal disease via endocannabinoid
| Project/Area Number |
20791619
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAKAJIMA Yumiko Kagoshima University, 医学部・歯学部附属病院, 医員 (40433081)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯周病 / 内因性カンナビノイド |
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| Research Abstract |
In this study, we focus on endocannainoid (anandamide(AEA), 2-AG) for an indicator of estimation of the relationship between Arteriosclerotic disease and Periodontal disease. We investigated the relationship between periodontal progression and AEA and 2-AG in periodontal pocket and total cholesterol, triglyceride, AEA and 2-AG inperipheral blood. None of significant relationship observed between periodontal progression and all of them.But they tend to increase proportionally with periodontal disease progression, especially in patient with heart disease. These results suggested that endocannabinoid are produced in periodontal pocket and these cannaibnoid affect systemic metabolism via blood flow.
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