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2009 Fiscal Year Final Research Report

Development of a Novel Method for Evaluating Cardiopulmonary Functions Using Hyperpolarized Xenon-129 Magnetic Resonance

Research Project

  • PDF
Project/Area Number 20800027
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

IMAI Hirohiko  Osaka University, 大学院・薬学研究科, 特任助教 (40506466)

Project Period (FY) 2008 – 2009
Keywords核磁気共鳴 / 超偏極希ガス / 肺機能診断 / 呼吸機能イメージング / 生体画像 / 慢性閉塞性肺疾患 / 肺気腫 / 心肺機能
Research Abstract

To develop the noninvasive method for evaluating cardiopulmonary functions using hyperpolarized xenon-129 magnetic resonance, several methods and analyses were applied to spontaneous breathing mice. As a result, these methods made possible to evaluate pulmonary functions regionally. Furthermore, the parameters related to pulmonary structure and cardiac function were successfully derived in the whole lung. From the application to pathological evaluation using a mouse model of emphysema, it was found that these parameters are the effective biomarker to detect emphysema.

  • Research Products

    (11 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Noninvasive Detection of Pulmonary Tissue Destruction in a Mouse Model of Emphysema Using Hyperpolarized129Xe MRS under Spontaneous Respiration2010

    • Author(s)
      Hirohiko Imai, et al. (6名)
    • Journal Title

      Magn Reson Med (掲載決定)

    • Peer Reviewed
  • [Journal Article] 3D Hyperpolarized 129Xe MRI of Mouse Lung at Low Xenon Concentration using a Continuous Flow-type Hyperpolarizing System: Feasibility for Quantitative Measurement of Regional Ventilation2009

    • Author(s)
      Yuki Hori, et al. (7名, 6番目)
    • Journal Title

      Magn Reson Med Sci 8巻

      Pages: 73-79

    • Peer Reviewed
  • [Presentation] 超偏極129Xe MRI/MRSを用いた肺気腫の包括的な評価2010

    • Author(s)
      今井宏彦, 他(7名)
    • Organizer
      第2回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-31
  • [Presentation] MRを用いた気道評価:He-3からXe-129へ2010

    • Author(s)
      藤原英明, 他(4名, 3番目)
    • Organizer
      第2回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-31
  • [Presentation] 超偏極129Xe MRIによるマウス肺の高速撮像と機能診断2009

    • Author(s)
      今井宏彦, 他(5名)
    • Organizer
      第37何日本磁気兵鳴医学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
  • [Presentation] マウス肺超偏極129Xeガス相・溶解相イメージングによる肺機能評価2009

    • Author(s)
      井口智史, 他(5名, 2番目)
    • Organizer
      第37回日本磁気共鳴医学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
  • [Presentation] Detection of Parameters Related to Lung Function and Structure as Applied to Emphysema Model Mice with Hyperpolarized 129Xe MRS Observed under Spontaneous Respiration2009

    • Author(s)
      Hirohiko Imai, et al. (6名)
    • Organizer
      ISMRM 17th Scientific Meeting
    • Place of Presentation
      Honolulu, HI, USA (ポスター賞ノミネート)
    • Year and Date
      2009-04-22
  • [Presentation] Hyperpolarized 129Xe Lung MRI with trueFISP on Spontaneous Breathing Mice by Means of Continuous Delivery of Xe Gas Polarized at Low Pressure2009

    • Author(s)
      Hirohiko Imai, et al. (7名)
    • Organizer
      ISMRM 17th Scientific Meeting
    • Place of Presentation
      Honolulu, HI, USA
    • Year and Date
      2009-04-22
  • [Presentation] 超偏極129Xe磁気共鳴法を用いた肺の構造と機能評価-肺気腫モデル動物への適用-2009

    • Author(s)
      今井宏彦, 他(7名)
    • Organizer
      第1回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-01-30
  • [Remarks]

    • URL

      http://sahswww.med.osaka-u.ac.jp/%7Ephy-chem/HP/menul.html

  • [Patent(Industrial Property Rights)] 偏極キセノンガスの濃縮方法、偏極キセノンガスの製造供給装置及びMRIシステム2009

    • Inventor(s)
      藤原英明, 今井宏彦, 井口智史, 吉村弘伸, 木村敦臣
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Industrial Property Number
      特許・PCT/JP2009/063482
    • Filing Date
      2009-07-29

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Published: 2011-06-18   Modified: 2016-04-21  

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