2009 Fiscal Year Final Research Report
Activity-dependent elimination of corticospinal synapses and NMDA receptor subtype
| Project/Area Number |
20800047
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Teikyo University |
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Principal Investigator |
OHNO Takae Teikyo University, 医学部, 助教 (60508109)
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| Project Period (FY) |
2008 – 2009
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| Keywords | corticospinal synapse / knockout mice / GluN2B (GluRε2 / NR2B) / GluN2A (GluRε1 / NR2A) / heterotypic co-culture / exo utero electroporation |
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| Research Abstract |
By using both GluN2B (ε2) and 2A (ε1) knockout mice for the in vitro corticospinal projection system, we concluded that that GluN2B in the spinal cord is selectively involved in the CS synapse elimination. We also found that this elimination process is CaMKII-dependent by pharmacological screening
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