2009 Fiscal Year Final Research Report
Roles of the serotonin synthesis emzyme, TphD2, in body patterning
| Project/Area Number |
20870024
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
MAEGAWA Shingo Kyoto University, 情報学研究科, 助教 (30467401)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 胚葉形成 / 原腸形成 / 体節形成 |
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| Research Abstract |
I found the following facts with zebrafish embryos. 1. Inhibitors of tryptophan hydroxylase or the antidepressant, Prozac, affected convergence during the body patterning. 2. A serotonin transporter, serta, which is the target for Prozac, is expressed during gastrulation. 3. Gastrula embryos produced serotonin. Based on the findings, I conclude that serotonin is involved in regulation of convergence movements during body patterning.
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