2009 Fiscal Year Final Research Report

The effect of nutritional management during fetal life on vascular function and oxidative stress in rats with adult-onset diseases

Research Project

Project/Area Number	20880030
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	Kinki University
Principal Investigator	SATOI Keiko Kinki University, 農学部, 助教 (70510874)
Project Period (FY)	2008 – 2009
Keywords	栄養生化学 / 栄養 / 循環器 / 高血圧
Research Abstract	Some research show that the increase in the prevalence of adult-onset diseases and vascular disorders after the birth by exposure to undernutrition during fetal life. Moreover, previous research using stroke-prone spontaneously hypertensive rats (SHRSP), an animal model which develops hypertension and stroke, demonstrated the increased salt-sensitivity in rats whose dams were fed protein restricted diets during pregnancy. In this study, the effect of maternal exposure to low-protein diet on postnatal vascular function was examined. As a result, the study revealed that nutritional environment during fetal life possibly affects vascular function independently of increased blood pressure in SHRSP with metabolic disorders.

(1 results)