2009 Fiscal Year Final Research Report
Cell-specific regulation of the JC virus late gene
| Project/Area Number |
20890005
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ORBA Yasuko Hokkaido University, 人獣共通感染症リサーチセンター, 博士研究員 (60507169)
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| Project Period (FY) |
2008 – 2009
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| Keywords | JCウイルス / T抗原 |
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| Research Abstract |
(1) Large T antigen of JC virus activates various promoters including JC virus late promoter. The enhancement of promoter activity by large T antigen is prominent in JC virus permissive cells. The cell-specific transcriptional regulation by T antigen is one of potential mechanisms of cell specificity for JC virus infection.
(2) We found that caffeine had a pronounced antiviral effect in cells infected with JC virus. Caffeine suppressed expression of viral early proteins and viral DNA replication.
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