2009 Fiscal Year Final Research Report
Structural changes of junctions between lymphatic endothelial cells in lymphatic invasion
| Project/Area Number |
20890056
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWATA Caname The University of Tokyo, 大学院・医学系研究科, 助教 (50511391)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌転移 / リンパ管 / 炎症 |
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| Research Abstract |
We hypothesize that the junctions between lymphatic endothelial cells are dilated in tumor environment and that the dilation help the invasion of cancer cells. We used the murine model of peritoneal inflammation and observed the structural changes in lymphatic vessels on the diaphragms. Stomatas, which are the entrance of initial lymphatic vessels on diaphragm, are dilated after the i.p. injection of proinflammatory agent. And the dilation is completely inhibited by treatment of sorafenib, a multikinase inhibitor.
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[Journal Article] Identification of targets of Prox1 during in vitro vascular diffe rentiation from embryonic stem cells : functional roles of HoxD8 in lymphan giogenesis2010
Author(s)
Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K
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Journal Title
Journal of Cell Science 112
Pages: 3923-3930
Peer Reviewed
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