2009 Fiscal Year Final Research Report
The Autocrine Mechanisms for Macrophage Migration Evoked by Mechanical Stretch of Atrial Myocytes.
| Project/Area Number |
20890061
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SASANO Tetsuo Tokyo Medical and Dental University, 難治疾患研究所, 特任助教 (00466898)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 心房細動 / 心房リモデリング / 細胞外ATP / オートクライン作用 |
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| Research Abstract |
Atrial dilatation is well-known contributor for atrial fibrillation, but its mechanism remains unclear. The aim of this study was to clarify the mechanism of atrial inflammation in stretched atrium. We found that mechanical stretch of atrial myocytes enhanced migration of macrophages. Further examinations revealed that atrial myocyte released ATP into the extracellular space, resulting in increased expression of chemokine by autocrine fashion. This mechanism may link between atrial dilatation and macrophage infiltration.
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[Journal Article] Integration of Infarct Size, Tissue Perfusion and Metabolism by Hybrid Cardiac PET-CT-Evaluation in a Porcine Model of Myocardial Infarction2009
Author(s)
Lautamaki R, Schuleri KH, Sasano T, Javadi MS, Youssef A, Merrill J, Nekolla SG, Abraham MR, Lardo AC, Bengel FM
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Journal Title
Circulation Cardiovascular imaging 2
Pages: 299-305
Peer Reviewed
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[Journal Article] Engraftment, differentiation and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy2009
Author(s)
Johnston PV, Sasano T, contributed equally, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Steenbergen C, Gerstenblith G, Lange R, Marban E.
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Journal Title
Circulation 120
Pages: 1075-83
Peer Reviewed
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[Journal Article] Abnormal Sympathetic Innervation of Viable Myocardium and the Substrate of Ventricular Tachycardia after Myocardial Infarction2008
Author(s)
Sasano T, Abraham MR, Chang KC, Ashikaga H, Mills KJ, Holt D, Hilton J, Nekolla S, Dong J, Lardo AC, Halperin HR, Dannals R, Marban E
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Journal Title
J Am Coll Cardiol 51
Pages: 2266-75
Peer Reviewed
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[Presentation] Identification of Substrate of Ventricular Tachycardia by Regional Strain MR Imaging in Infarct Porcine Heart2009
Author(s)
Sasano T, Chang KC, Youssef A, Abd-Elmoniem KZ, Vonken E, Mills KJ, Osman NF, Stuber M, Halperin H, Calkins H, Abraham MR, Marban E.
Organizer
Gordon Research Conference 2009
Place of Presentation
イタリア
Year and Date
20090200
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