2009 Fiscal Year Final Research Report
Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation
| Project/Area Number |
20890096
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
NISHIDA Tetsuya Nagoya University, 医学部・附属病院, 医員 (80508929)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 臍帯血移植 / 腫瘍反応性T細胞 / 抗原提示細胞 / 成人T細胞性白血病 / サイトメガロウイルス / CTLA-4 |
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| Research Abstract |
Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation was analyzed using adult T cell leukemia (ATL) cells. ATL cells activated with CD3/CD28 maintained characteristics of ATL and acquired the potential as an antigen presenting cells. ATL reactive T cells were not generated from post-transplant peripheral blood mononuclear cells isolated from ATL patients with clinical response. Immune reaction against cytomegalovirus after cord blood transplantation was also weaker than that after bone marrow transplantation and peripheral blood stem cell transplantation
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