2009 Fiscal Year Final Research Report
The association between TSP1 polymorphism and treatment efficacy of heart failure
| Project/Area Number |
20890115
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
NONEN Shinpei Osaka University, 薬学部, 講師 (40467527)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 心不全 / β遮断薬 / TSP1 / 遺伝子多型 |
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| Research Abstract |
I investigate the association between inter-individual variability of ss-blocker responsiveness in heart failure and TSP1 Thr523Ala polymorphism. I also perform in vitro functional analysis of TSP1 Thr523Ala. TSP1 Thr523Ala was associated with response to β-blockers in heart failure. Ala-523 TSP1 construct was lower in protein expression and translation efficacy than Thr-523 TSP1 construct.
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