Spinal ceramide is responsible for the development of neuropathic pain.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20890200
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: KOBAYASHI Yuka Wakayama Medical University, 医学部, 助教 (20511562)
• Project Period (FY): 2008 – 2009
• Keywords: 神経障害性疼痛 / スフィンゴ脂質 / グリア細胞 / サイトカイン / アロディニア

Research Abstract

In this study, the involvement of spinal ceramide in neuropathic pain through microglia activation and inflammatory cytokines increase was revealed. Therefore, ceramide was nominated as a novel therapeutic target of neuropathic pain.

Research Products

• [Journal Article] Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta. (2010)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Pain. 149(2) Pages: 305-315
  • Peer Reviewed
• [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. (2009)
  • Author(s): Maeda T, Kiguchi N, Kobayashi Y, et al.
  • Journal Title: Proc. Natl. Acad. Sci. USA 106(31) Pages: 13076-13081
  • Peer Reviewed
• [Journal Article] Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. Biochem. Biophys. (2009)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Res. Commun. 384(3) Pages: 311-315
  • Peer Reviewed
• [Journal Article] Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice. (2009)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Anesth. Analg. 109(4) Pages: 1305-1311
  • Peer Reviewed
• [Journal Article] Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice. (2009)
  • Author(s): Saika F, Kiguchi N, Kobayashi Y, et al.
  • Journal Title: Biol. Pharm. Bull. 32(7) Pages: 1231-1234
  • Peer Reviewed
• [Journal Article] Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury. (2008)
  • Author(s): Iwai S, Maeda T, Kiguchi N, Kobayashi Y, et al.
  • Journal Title: Drug Discov. Ther. 2(6) Pages: 353-356
  • Peer Reviewed
• [Journal Article] Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury. (2008)
  • Author(s): Maeda T, Kiguchi N, Kobayashi Y, et al.
  • Journal Title: J. Pharmacol. Sci. 108(3) Pages: 341-347
  • Peer Reviewed
• [Journal Article] Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice. (2008)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Neurosci. Lett. 445 Pages: 140-143
  • Peer Reviewed
• [Journal Article] The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. (2008)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Eur. J. Pharmacol. 592(1-3) Pages: 87-92
  • Peer Reviewed
• [Presentation] HMGB1によるレプチンシグナル活性化は神経障害性疼痛の形成に関与する. (2010)
  • Author(s): 前田武彦, 木口倫一, 小林悠佳, 岸岡史郎
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100316-20100318
• [Presentation] レプチンはマクロファージにおけるIL-1βおよびMIP-1αの発現を増加させる. (2010)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100316-20100318
• [Presentation] セラミドは脊髄ミクログリアの活性化および炎症性サイトカインの遊離を介して神経障害性疼痛を調節する. (2010)
  • Author(s): 小林悠佳, 木口倫一, 前田武彦, 岸岡史郎
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100306-20100318
• [Presentation] シュワン細胞におけるERKの活性は坐骨神経結紮による神経障害性疼痛に関与する. (2009)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] CCケモカインMIP-1βは末梢神経傷害後のアロディニア形成を促進する. (2009)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第30回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20090828-20090829
• [Presentation] 神経障害性疼痛におけるMIP-1αの関与. (2009)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20090316-20090318
• [Presentation] 神経障害性疼痛におけるセラミドの関与. (2009)
  • Author(s): 小林悠佳, 木口倫一, 前田武彦, 岸岡史郎
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: 大津
  • Year and Date: 2009-11-13
• [Presentation] MIP-1αの介在する神経障害性疼痛形成機構におけるマクロファージの役割. (2009)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: 金沢
  • Year and Date: 2009-06-26
• [Presentation] Involvement of CC chemokine ligand 3 (CCL3) and 4 (CCL4) in nerve injury-induced neuropathic pain. (2008)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, Kishioka S
  • Organizer: XI Workshop on Apoptosis in Biology and Medicine
  • Place of Presentation: 仙台
  • Year and Date: 20080912-20080914
• [Presentation] アディポサイトカインによるアロディニア形成の調節. (2008)
  • Author(s): 前田武彦, 木口倫一, 小林悠佳, 岸岡史郎
  • Organizer: 第29回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 富山
  • Year and Date: 20080829-20080830
• [Presentation] 神経因性疼痛行動に及ぼすケモカインCCL3/MIP-1αの影響 (2008)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第29回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 富山
  • Year and Date: 20080829-20080830
• [Presentation] 坐骨神経部分結紮モデルマウスにおけるCCケモカインリガンドおよびその受容体発現増加. (2008)
  • Author(s): 木口倫一, 小林悠佳, 前田武彦, 岸岡史郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-20080711
• [Presentation] レプチンシグナルにより増加するケモカインCCL3/MIP-1αは神経因性疼痛の形成に関与する. (2008)
  • Author(s): 木口倫一, 前田武彦, 小林悠佳, 岸岡史郎
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] レプチンの神経因性疼痛増悪作用のメカニズム解明. (2008)
  • Author(s): 前田武彦, 木口倫一, 小林悠佳, 岸岡史郎
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Book] Chapter 14 Involvement of inflammatory mediators in neuropathic pain caused by vincristine. (2009)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, Saika F, Kishioka S
  • Total Pages: 179-190
  • Publisher: Int. Rev. Neurobiol.
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html