2009 Fiscal Year Final Research Report
Mechanism for novel sterols induced anchorage-independent cancer cell death
| Project/Area Number |
20890207
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TANAKA Aro Iwate Medical University, 薬学部, 助手 (60509040)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌 / シグナル伝達 / anoikis / P38mapk / Rho |
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| Research Abstract |
Anicequol is a terpenoid derived from fungus. We aimed the elucidation of the mechanism underlying anicequol induced anoikis in colon cancer cell lines DLD1 and HT29. As a result, we showed that the p38MAPK pathway is associated with anicequol induced anoikis. In addition, Rho-kinase inhibitor Y27632 inhibited anicequol induced anoikis, suggesting that p38MAPK pathway links Rho pathway.
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