2009 Fiscal Year Final Research Report
Functional analysis of Rho signaling in morphological change and migration of odontoblasts
| Project/Area Number |
20890208
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
OTSU Keishi Iwate Medical University, 歯学部, ポストドクター (60509066)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 発生・分化 / 歯学 / 細胞・組織 / シグナル伝達 / 象牙芽細胞 / 歯胚発生 / Rhoシグナリング / real time imaging |
|---|
| Research Abstract |
We have developed a new system that can observe the morphological change and molecular dynamics in a single cell during odontogenesis. We have established odontoblasts cell line from tooth germ mesenchymal cells with odontoblast marker. Using the cell line and mouse incisor organ culture, we demonstrated that ROCK, an effecter molecule of Rho small GTPase, plays an important role for the polarization and odontogenesis.
|
