2009 Fiscal Year Final Research Report
Molecular mechanism of switch in the mode of human papillomavirus DNA replication
| Project/Area Number |
20890289
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MATSUO Rika (楠本 理加) National Institute of Infectious Diseases, 病原体ゲノム解析研究センター, 厚生労働技官 (90514133)
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| Project Period (FY) |
2008 – 2009
|
| Keywords | 子宮頸癌 / ヒトパピローマウイルス / DNA複製 |
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| Research Abstract |
To dissect a profile of DNA replication of human papillomavirus (HPV), which is the responsible virus for cervical cancer, in the epithelium cells, we analyzed replication of an HPV origin-containing plasmid in extracts prepared from the cells. HPV DNA replicates with two modes in epithelial cells. One of the modes was inhibited in human embryonic kidney 293 cells, suggesting that the mode is specific to epithelial cells.
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