2020 Fiscal Year Annual Research Report
神経突起・神経炎症イメージングによるパーキンソン病の病態解明
| Project/Area Number |
20F20113
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| Research Institution | Juntendo University |
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Principal Investigator |
鎌形 康司 順天堂大学, 医学部, 准教授 (60568153)
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| Co-Investigator(Kenkyū-buntansha) |
ANDICA CHRISTINA 順天堂大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2020-04-24 – 2022-03-31
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| Keywords | Parkinson’s disease / Tremor dominant / Diffusion tensor imaging / Fixel-based analysis / Free-water imaging / Neurall plasticity / Neuroinflammation |
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| Outline of Annual Research Achievements |
We assessed the fiber-specific white matter (WM) alterations in patients with early-stage Parkinson’s disease (PD) with tremor dominant using fixel-based analysis. As a result, we provided evidence of WM neural compensation mechanisms marked by increases in neuronal fiber bundle size. In contrast, no such finding was found in PD patients with postural instability and gait disorder (minor revision of npj Parkinson’s disease journal). Using free-water imaging, we also showed neuroinflammation (indexed by increased free-water fractional volume fraction) in the substantia nigra pars compacta, temporal mesocortex, forceps major, and cingulum cingulate gyrus correlated with the motor assessment scale in patients with PD with GBA1 mutations (presented in 2021 ISMRM Annual Meeting & Exhibition).
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
In the first year, we have successfully evaluated the cross-sectional data of patients with early-stage Parkinson’s disease (PD) using advanced diffusion MRI techniques as planned. We have also considered different subtypes of PD, such as tremor dominant vs. postural instability and gait disorder and idiopathic PD vs. familial PD. Our findings provided important new insights into neuropathological changes (such as neuronal morphology alterations and neuroinflammation) associated with PD subtypes and showed the association between the changes and clinical scores. As scheduled, we have presented these findings at conferences and prepared the manuscripts.
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| Strategy for Future Research Activity |
As planned, we will evaluate the longitudinal data of Parkinson’s disease (PD) using advanced diffusion MRI techniques in the second year. In line with the cross-sectional study, we will also assess the longitudinal neuropathological changes of different subtypes of PD. We expect to publish more articles by the end of the fiscal year.
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