2021 Fiscal Year Annual Research Report
神経突起・神経炎症イメージングによるパーキンソン病の病態解明
| Project/Area Number |
20F20113
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| Research Institution | Juntendo University |
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Principal Investigator |
鎌形 康司 順天堂大学, 医学部, 准教授 (60568153)
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| Co-Investigator(Kenkyū-buntansha) |
ANDICA CHRISTINA 順天堂大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2020-04-24 – 2022-03-31
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| Keywords | Parkinson's disease / Diffusion MRI / Free water imaging / Neurite imaging / Fixel-based analysis |
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| Outline of Annual Research Achievements |
This research applied neurite orientation dispersion and density imaging, free-water imaging, and fixel-based analysis to baseline and follow-up data of subjects with Parkinson's disease (PD). As results of cross-sectional studies, we showed different patterns of brain tissue microstructural changes (i.e., neuronal loss and neuroinflammation) in different clinical subtypes of PD (i.e., with vs. without neurocognitive and psychiatric symptoms, tremor dominant vs. postural instability and gait disorder motor subtypes, with vs. without mild cognitive impairment, and with vs. without glucocerebrosidase gene mutations). Furthermore, in a longitudinal analysis, we demonstrated white matter neural compensation among PD patients with normal cognition one year after diagnosis.
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| Research Progress Status |
令和3年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
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[Journal Article] Comparison of Brain Volume Measurements Made with 0.3- and 3-T MR Imaging2021
Author(s)
Murata Syo、Hagiwara Akifumi、Kaga Hideyoshi、Someya Yuki、Nemoto Kiyotaka、Goto Masami、Kamagata Koji、Irie Ryusuke、Hori Masaaki、Andica Christina、Wada Akihiko、Kumamaru Kanako Kunishima、Shimoji Keigo、Otsuka Yujiro、Hoshito Haruyoshi、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Aoki Shigeki
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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