2023 Fiscal Year Final Research Report
Comprehensive understanding of oxidized lipids involved in disease induction
| Project/Area Number |
20H00493
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 47:Pharmaceutical sciences and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今井 浩孝 北里大学, 薬学部, 教授 (50255361)
柴田 貴広 名古屋大学, 生命農学研究科, 教授 (80447838)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 酸化脂質 / 構造解析 |
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| Outline of Final Research Achievements |
Unsaturated fatty acids are readily oxidized to produce a variety of metabolites. Recently, it has been reported that these oxidized lipids are closely involved in the induction of inflammation, cell death, and even disease development. However, because oxidized lipids are highly reactive and in tiny amounts, there is no appropriate measurement method, and little progress has been made in research. In this study, we aimed to develop the structural analysis method of oxidized lipids, identify oxidized lipid molecules in animal disease models, and understand how these oxidized lipid molecules act, in other words, to "comprehensively understand oxidized lipids involved in disease induction."
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| Free Research Field |
脂質分析学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果から、非常の多く酸化脂質の検出・構造解析に成功し、実際に疾患モデル動物でも数十種類を超える分子が生成していることが判った。このことは、これまで未知であった酸化脂質の機能解明に向けた新たな方法論を提案することができたと言える。今後、その機能を解明することにより、酸化脂質の生体内での役割や受容体をターゲットとした創薬研究への展開も可能になるであろう。さらに、なぜ不飽和脂肪酸は酸化障害を最も受けやすい細胞膜に存在し、かつ酸化されやすい構造をしているのか、という学術的な問いへの解にも近づいたと考えている。
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