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2022 Fiscal Year Final Research Report

Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease

Research Project

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Project/Area Number 20H00553
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionKyushu University

Principal Investigator

Nakamura Seiji  九州大学, 歯学研究院, 教授 (60189040)

Co-Investigator(Kenkyū-buntansha) 前原 隆  九州大学, 歯学研究院, 助教 (10637333)
新納 宏昭  九州大学, 医学研究院, 教授 (20380636)
森山 雅文  九州大学, 大学病院, 助教 (20452774)
柴田 琢磨  東京大学, 医科学研究所, 助教 (30554505)
安河内 友世 (川久保友世)  九州大学, 歯学研究院, 准教授 (70507813)
坪井 洋人  筑波大学, 医学医療系, 准教授 (80580505)
Project Period (FY) 2020-04-01 – 2023-03-31
KeywordsIgG4関連疾患 / T細胞 / B細胞 / マクロファージ / TLR7
Outline of Final Research Achievements

IgG4-related diseases is a unique systemic disease characterized by mass formation and consequent dysfunction of multiple organs, as well as severe fibrosis with infiltrating T cells, B cells, and macrophages. Currently, no effective treatment is available. In this study, we focused on a subset of unique T cells, B cells, and macrophages and performed single-cell RNA sequencing as well as T-B receptor sequencing to obtain a comprehensive, unbiased view of tissue infiltrating cells. As a result, we identified characteristic T and B cell subsets. We also focused on macrophages expressing Toll-like receptor 7 and tested whether it is possible to generate mice that can reproduce the pathology by stimulating them with TLR7 agonist.

Free Research Field

臨床免疫学

Academic Significance and Societal Importance of the Research Achievements

IgG4関連疾患の罹患臓器に浸潤する全T細胞、B細胞、マクロファージを明らかにし、我々が作成したIgG4関連疾患のモデルマウスを用いて特異な細胞群にフォーカスして実際に病態が再現できれば、新たな治療標的薬の開発が可能となる。

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Published: 2024-01-30  

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