Development of Reaction Pathways Involving New Catalyst Metal Migrations Toward Selective Synthesis of Functional Organic Molecules

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H02741
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Osaka University
• Principal Investigator: Shintani Ryo 大阪大学, 大学院基礎工学研究科, 教授 (50372561)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 選択的合成 / 転位反応 / 機能性有機分子

Outline of Final Research Achievements

Organic compounds are used in various fields such as medical/agricultural products and organic materials. Therefore, further progress in synthetic organic chemistry greatly contributes to the development of various related fields. In particular, precise synthetic organic reactions with high selectivity are desirable molecular-transforming processes with high efficiency. Among them, rearrangement and isomerization reactions where catalyst metals migrate within organic molecules during the reactions are very attractive because they enable a new way of constructing molecules by activating the bonds that are otherwise difficult to utilize. In this research, investigations toward the development of synthetically valuable catalytic reactions were carried out based on this approach, and several new reactions with high selectivity were successfully developed.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、有機化合物を合成する反応の過程において触媒として用いる金属が有機分子内を移動しながら新しい分子骨格を構築する手法を開発し、それによって様々な有用物質の新規合成を行うことに成功した。その成果は、学術的な新規性が高いばかりでなく、従来の分子変換プロセスにとらわれない、新しい分子設計や合成経路の設定を可能とするため、有機合成化学はもちろん、有機材料化学などの関連諸分野に対する波及効果も大きい。