2023 Fiscal Year Final Research Report
Development and application of novel tools for pathophysiological investigation of the brain by an alkyne-tagging approach
Project/Area Number |
20H02881
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 37030:Chemical biology-related
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Research Institution | Keio University |
Principal Investigator |
Nuriya Mutsuo 慶應義塾大学, 医学部(信濃町), 准教授 (60453544)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | アルキンタグ / 脳 / プローブ / 生理活性物質 |
Outline of Final Research Achievements |
The intercellular communication within the brain underlies our cognitive and mental functions, and its dysfunction is considered to cause various neurological and psychiatric disorders. However, due to technical constraints, observing and analyzing such communications has been challenging. In this study, we successfully developed a novel labeling method based on the fusion of chemistry and biology, known as chemical biology, to visualize the substances responsible for chemical communications. By using this method, we gained new insights into the detailed properties of intercellular communications including their sites of actions.
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Free Research Field |
薬理学
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果の意義は、手法の開発とその応用の両面にある。まず、手法の面では、これまで重要性が理解されながら可視化解析ができなかったサイズの小さな生理活性物質の可視化を実現するアルキンタグという新たな簡便な手法を提供した。これにより、今後の生理活性物質の研究の発展に貢献することができると期待される。次に、開発に成功したドーパミンとオキシトシンの可視化ツールについては、それを利用することで脳内での作用に関しての新たな生物学的知見をもたらすのみならず、今後、薬剤の開発などに広く応用できるツールを提供することとなった。
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