2022 Fiscal Year Final Research Report
Functional difference of sperm revealed by novel GPI-anchored proteins
| Project/Area Number |
20H03163
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 42030:Animal life science-related
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| Research Institution | Kyoto University |
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Principal Investigator |
Kondo Gen 京都大学, 医生物学研究所, 教授 (40243258)
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| Co-Investigator(Kenkyū-buntansha) |
竹尾 透 熊本大学, 生命資源研究・支援センター, 教授 (10517014)
岡本 宗裕 京都大学, ヒト行動進化研究センター, 教授 (70177096)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 受精 / 精子 / 精子表面タンパク質 / 人工授精 / 体外受精 / マウス / サル / GPIアンカー型タンパク質 |
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| Outline of Final Research Achievements |
This study showed that mouse sperm populations were divided into two groups (high sperm and low sperm) based on differences in SpGPI-AP expression levels. The high spermatozoa appeared in a Ca ion-dependent manner and negatively regulated fertilization in vivo. It was a unique population with five different surface molecules that co-expressed with SpGPI-AP during sperm activation. We also showed that a similar sperm population exists in monkeys. This phenomenon is considered to be independent of conventional capacitation and acrosomal reaction, suggesting the existence of a new fertilization control mechanism in mammals.
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| Free Research Field |
実験動物学
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| Academic Significance and Societal Importance of the Research Achievements |
不妊症の約３０％は原因不明の男性不妊によるものと考えられている。本研究について
現在特許出願を考えており、その予備調査において複数の男性不妊専門医からこの研究成果の早期の開示が要請された。本研究では、ヒトに近縁のサルにおいてマウスと同様の現象が認められたことから、将来不妊症診断や治療法開発につながる可能性が高いと考えられ、社会的意義も大きいと思われる。
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