2023 Fiscal Year Final Research Report
Molecular mechanisms of novel diacylglycerol phosphorylation pathways that control various physiological and pathological phenomena
| Project/Area Number |
20H03205
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 43030:Functional biochemistry-related
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| Research Institution | Chiba University |
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Principal Investigator |
Sakane Fumio 千葉大学, 大学院理学研究院, 教授 (10183815)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ジアシルグリセロールキナーゼ / ジアシルグリセロール / ホスファチジン酸 / がん免疫 / セロトニン神経系 / ドパミン神経系 / 糖尿病 / ホスファチジルコリン特異的ホスホリパーゼC |
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| Outline of Final Research Achievements |
Recently, using a newly developed unique method, diacylglycerol (DG) molecular species, which are the substrates of diacylglycerol kinase (DGK) isozymes, were found to be supplied by phosphatidylinositol (PI) turnover-independent pathways, each of which utilizes a different fatty acid. However, there are still many unknown issues regarding the constituent factors and molecular machinery of these pathways. Therefore, we have clarified these issues. For example, we identified sphingomyelin synthase isozymes as an upstream DG-producing enzyme and synaptojanin 1 as a downstream PA-binding protein.
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| Free Research Field |
生化学
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| Academic Significance and Societal Importance of the Research Achievements |
これまで誰も気づいておらず注目していなかった「PI代謝回転とは独立し，それぞれが異なる脂肪酸を利用する未知の経路群」の存在とそれらの経路の構成因子や分子マシーナリーを明らかにしたことは，新規性が高く新たな研究領域を開拓する可能性があり，学術的意義も大きい．また，各DGKアイソザイムは様々な病気（例えば，2型糖尿病，双極性障害，パーキンソン病，がん等）に関連しているので，それらが構成する経路群の詳細を明らかにすることは新たな治療法の開発に貢献する等，社会的意義も大きい．
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