2022 Fiscal Year Final Research Report
Regulation of mitochondrial quality control by cellular signals
| Project/Area Number |
20H03257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 44010:Cell biology-related
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ミトコンドリア品質管理 |
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| Outline of Final Research Achievements |
Damaged mitochondria are selectively eliminated by autophagy, which is called mitochondrial quality control. It remains unclear how mitochondrial quality is controlled through cellular signaling pathways. We focused on a glycolytic enzyme and showed its mitochondrial targeting and involvement in mitochondrial quality control. Furthermore, we found that ubiquitination onto mitochondrial outer membrane proteins was stimulated under hypoxic conditions.
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| Free Research Field |
分子細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，細胞内外の多様な環境変化に起因する異なるシグナル経路に着目して，ミトコンドリア機能の調節機構を明らかにしようとする点が特徴であり，特にミトコンドリアの代謝経路の上流である解糖系および下流の酸素消費との関連性を検証した点がユニークである。本研究で得られる結果は，ミトコンドリアの機能と品質管理の理解に寄与するだけでなく，PINK1やParkinを原因遺伝子とする遺伝性パーキンソン病の発症メカニズムを理解する一助となることが期待される。
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