The dynamics and function of newly synthesized proteins in long-lasting memory

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03337
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Niigata University
• Principal Investigator: Mikuni Takayasu 新潟大学, 脳研究所, 教授 (90786477)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 分子イメージング

Outline of Final Research Achievements

Memories can be divided into short-term memory, lasting for seconds to minutes, and long-term memory, lasting for hours, days or even a lifetime. Short-term memory is protein synthesis-independent, while long-term memory is protein synthesis-dependent. However, it is largely unknown when, where and how distinct newly synthesized proteins work for long-term memory. In this study, we established a high-throughput method for imaging newly synthesized proteins in brain tissue, enabling the monitoring of a variety of newly synthesized proteins in the brain in the context of long-lasting memory.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

何時間、何日、あるいは一生続くような長期記憶の形成には、脳内でタンパク質が新規に合成される必要があることが知られている。しかしながら、脳内で個々の新規合成タンパク質を選択的に観察する良い方法はこれまでなかった。本研究では、一定の時間枠の間に脳内で合成された新規合成タンパク質を脳内で選択的に観察するための方法を開発し、長期記憶の研究の礎を築いた。