2022 Fiscal Year Final Research Report
Development of anti-cancer drug targeting cancer stem cells
Project/Area Number |
20H03407
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | Gifu Pharmaceutical University |
Principal Investigator |
HINOI Eiichi 岐阜薬科大学, 薬学部, 教授 (70360865)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | がん幹細胞 |
Outline of Final Research Achievements |
Glioblastoma (GBM) is the most common high-grade malignant glioma in adults. Emerging evidence indicates that glioma-initiating cell (GICs) contribute to glioblastoma initiation, progression and recurrence owing to their self-renewal capacity and tumorigenicity. SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) belongs to the E3 ubiquitin ligase family. We have previously demonstrated that phosphorylation of SMURF2 at Thr249 activates its E3 ubiquitin ligase activity. Here, we show that the importance of SMURF2Thr249 phosphorylation in maintenance of stemness and tumorigenicity of GICs, and a potential target for GIC-directed therapy.
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Free Research Field |
薬理学
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Academic Significance and Societal Importance of the Research Achievements |
グリオーマだけでなく急性骨髄性白血病、乳がんや前立腺がんなどにおいても、その病態とがん幹細胞特性に緊密な関連性があることが報告されている。本研究の遂行によって、「GICの幹細胞性調節機構の解明」によりGBMのような難治性がんに対する新規治療標的が明確になるだけでなく、がん幹細胞制御および、がん進展制御への包括的な理解が進み、グリオーマだけでなく、がん幹細胞が関与する様々ながんに対する根本的治療法開発への展開が期待される。
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