2023 Fiscal Year Final Research Report
Understanding Neural Circuit Alterations Caused by Chronic Nicotine Exposure from the Developmental Period
| Project/Area Number |
20H03410
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮崎 太輔 北海道大学, 保健科学研究院, 准教授 (90374230)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | シナプス / ニコチン / アセチルコリン |
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| Outline of Final Research Achievements |
icotinic acetylcholine receptors exert various neurotransmitter-modifying effects by binding to nicotine, the main component of tobacco. In addition to the well-known nicotine dependence, it has recently been suggested that nicotine exposure from the developmental period may provide a new possibility of a pathway to opioid and other drug dependence, but the biological mechanism, its localization in the brain, and its molecular mechanisms are still unknown. In this study, we aim to elucidate the structural and functional mechanisms of neurotransmitter modification via nicotinic acetylcholine receptors and how nicotine exposure from the developmental period alters neural circuits. a3b4 receptors, which are thought to define the upper limit of nicotine intake. The expression patterns of these receptors, which are thought to regulate the upper limit of nicotine intake, were clarified in the adult mouse brain.
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| Free Research Field |
神経解剖学
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| Academic Significance and Societal Importance of the Research Achievements |
ニコチン依存に関わるニコチン性アセチルコリン受容体の脳内での発現パターンを理解することは、依存症のメカニズムを解明し、より効果的な対策を講じるための重要なステップとなります。例えば、特定の受容体に作用する新しい治療薬を開発することで、より効果的で副作用の少ない治療法が提供できるようになります。また受容体の発現パターンに基づく治療法の発展により、依存症からの回復が促進され、精神的健康の改善が期待されます。さらに依存症予防策の強化につながり、関連する医療費や社会的コストが削減されます。今回得られた解剖学的な知見を活用することで、社会全体の健康と福祉を向上させることが期待されます。
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