2022 Fiscal Year Final Research Report
Molecular mechanism of cell death-induced tissue remodeling in metabolic syndrome
| Project/Area Number |
20H03447
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49010:Pathological biochemistry-related
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 慢性炎症 / メタボリックシンドローム / マクロファージ |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms of chronic inflammation associated with overnutrition, this study focused on the unique histological feature "crown-like structure (CLS)" observed in obesity and non-alcoholic steatohepatitis (NASH), and investigated the molecular mechanism of CLS formation and its pathophysiological significance. Specifically, we addressed (1) the application of the plant-derived flavonoid taxifolin to the treatment of NASH, (2) the functional significance of iron-rich macrophages in NASH, and (3) the mechanism of hepatic fibrosis induced by altered macrophage cholesterol metabolism.
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| Free Research Field |
病態医化学
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| Academic Significance and Societal Importance of the Research Achievements |
現在、NASHの病態メカニズムは未だ不明の点が多く、厚労省に認可されたNASH治療薬も存在しない。本研究では、既に健康食品として世界中で使用されているタキシフォリンが抗メタボリックシンドローム効果に加えて、抗NASH効果も有することを初めて明らかにするとともに、CLSが薬効評価の点で有用であることを示した。また、鉄やコレステロールに着目してNASH病態メカニズムの一端を明らかにし、新たな治療戦略の創出につながると期待できる。
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