2022 Fiscal Year Final Research Report
Pathological mechanism of neurodevelopmental disorders caused by the disruption of neuroimmune system
Project/Area Number |
20H03570
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
Tanabe Shogo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 室長 (40772166)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 脳発達障害 / 脳内免疫システム |
Outline of Final Research Achievements |
Although abberant immune responses during brain development inhibit normal brain development and create neural circuits that do not normally form, leading to neurodevelopmental disorders, the molecular mechanisms have been unclear. In this study, we elucidated the molecular mechanisms by which abnormalities in the neuroimmune system cause neurodevelopmental disorders by focusing on autism spectrum disorders and neonatal meningitis. We observed behavioral abnormalities due to inflammation in developing brain, and identified the neural circuits that cause brain developmental disorders and their molecular mechanisms through cell culture experiments, cell depletion, neural tracing experiments, and RNA-seq analysis.
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Free Research Field |
神経科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、自閉症スペクトラム障害や髄膜炎を対象に免疫系の異常に伴う脳発達障害の発症メカニズムを解明した。免疫系による異常な神経回路形成のメカニズムを分子レベルで解明することで発達期の炎症によって引き起こされる脳発達障害の発症を予防する新たな治療標的が発見されることが期待される。
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