2023 Fiscal Year Final Research Report

Study on vulnerability and predictive factors for neurodevelopmental disorders

Research Project

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Project/Area Number	20H03595
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 52030:Psychiatry-related
Research Institution	Hirosaki University
Principal Investigator	Nakamura Kazuhiko 弘前大学, 医学研究科, 教授 (80263911)
Co-Investigator(Kenkyū-buntansha)	上野伸哉弘前大学, 医学研究科, 教授 (00312158) 斉藤まなぶ弘前大学, 保健学研究科, 教授 (40568846) 古川智範弘前大学, 医学研究科, 助教 (60402369) 下山修司弘前大学, 医学研究科, 助教 (60736370) 坂本由唯弘前大学, 医学部附属病院, 講師 (60770386) 足立匡基弘前大学, 保健学研究科, 准教授 (50637329) 高橋芳雄弘前大学, 保健学研究科, 准教授 (70760891)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	神経発達症群 / 自閉症 / 注意欠如・多動症 / メタボローム解析 / 5歳児発達健診
Outline of Final Research Achievements	The 5-year-old developmental check-up was held annually in a certain city. We analyzed serum, genetic and other data of the neurodevelopmental disorder group for tenth years. Metabolomic analysis of plasma revealed that a group of amino acids had significant differences in ASD, and biogenic amines and fatty acids indicated significant differences in ADHD. Significant differences were found in four factors for the coexistence of ASD and ADHD. Furthermore, a correlation was found between sleep and ferritin in the neurodevelopmental disorder group, and a positive correlation was found between oxytocin levels and Conners' hyperactivity in girls in the ASD group.
Free Research Field	子どもの精神医学
Academic Significance and Societal Importance of the Research Achievements	2次発達健診で神経発達障害群の診断がついた5歳児約650名の血漿をメタボローム解析することでASD、ADHDの診断マーカーもしくは病態解明につながる因子がいくつか明らかになった。ASD、ADHDと睡眠やオキシトシン値との関連もわかり、ASDやADHDの病態解明につながる結果が得られたことは学問的意義があり、ASDとADHDは同じ群にあり、臨床的にそれを意識することは臨床的にも意義があり、社会に還元できる。