• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Study on vulnerability and predictive factors for neurodevelopmental disorders

Research Project

  • PDF
Project/Area Number 20H03595
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionHirosaki University

Principal Investigator

Nakamura Kazuhiko  弘前大学, 医学研究科, 教授 (80263911)

Co-Investigator(Kenkyū-buntansha) 上野 伸哉  弘前大学, 医学研究科, 教授 (00312158)
斉藤 まなぶ  弘前大学, 保健学研究科, 教授 (40568846)
古川 智範  弘前大学, 医学研究科, 助教 (60402369)
下山 修司  弘前大学, 医学研究科, 助教 (60736370)
坂本 由唯  弘前大学, 医学部附属病院, 講師 (60770386)
足立 匡基  弘前大学, 保健学研究科, 准教授 (50637329)
高橋 芳雄  弘前大学, 保健学研究科, 准教授 (70760891)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywords神経発達症群 / 自閉症 / 注意欠如・多動症 / メタボローム解析 / 5歳児発達健診
Outline of Final Research Achievements

The 5-year-old developmental check-up was held annually in a certain city. We analyzed serum, genetic and other data of the neurodevelopmental disorder group for tenth years. Metabolomic analysis of plasma revealed that a group of amino acids had significant differences in ASD, and biogenic amines and fatty acids indicated significant differences in ADHD. Significant differences were found in four factors for the coexistence of ASD and ADHD. Furthermore, a correlation was found between sleep and ferritin in the neurodevelopmental disorder group, and a positive correlation was found between oxytocin levels and Conners' hyperactivity in girls in the ASD group.

Free Research Field

子どもの精神医学

Academic Significance and Societal Importance of the Research Achievements

2次発達健診で神経発達障害群の診断がついた5歳児約650名の血漿をメタボローム解析することでASD、ADHDの診断マーカーもしくは病態解明につながる因子がいくつか明らかになった。ASD、ADHDと睡眠やオキシトシン値との関連もわかり、ASDやADHDの病態解明につながる結果が得られたことは学問的意義があり、ASDとADHDは同じ群にあり、臨床的にそれを意識することは臨床的にも意義があり、社会に還元できる。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi