An imaging-genetic study using polygenic risk scores in trio samples of bipolar disorder

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H03605
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Saitama Medical University
• Principal Investigator: MATSUO Koji 埼玉医科大学, 医学部, 教授 (00292912)
• Co-Investigator(Kenkyū-buntansha): 加藤 忠史 順天堂大学, 医学部, 教授 (30214381) ; 松岡 孝裕 埼玉医科大学, 医学部, 准教授 (90255092) ; 小澤 栄人 埼玉医科大学, 医学部, 教授 (90255109) ; 下出 崇輝 埼玉医科大学, 医学部, 助教 (20870314)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 双極性障害 / 神経画像 / 遺伝子 / リスクスコア / 背外側前頭前野 / 前部帯状回

Outline of Final Research Achievements

The goal of this study is to identify genetic risk and associated brain regions using neuroimaging and genetic risk scores of patients, siblings, and parents to elucidate the biological basis of bipolar disorder. We are currently working with 10 trio samples, and although we are still 5 trio samples short of our goal, we are conducting preliminary analyses. We hypothesize that people with high genetic risk scores will have abnormalities in brain regions associated with the biological basis of bipolar disorder, such as anterior cingulate, dorsolateral prefrontal cortex, and amygdala.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、双極性障害の生物学的基盤が脳の病態及び遺伝子との関連について強固なエビデンスを得ることができ、双極性障害の原因解明やその後の治療法の開発の端緒となる。